Samuel Jessurun de Mesquita (6 June 1868 – c. 11 February 1944) was a Dutch graphic artist active in the years before the Second World War. His pupils included graphic artist M. C. Escher (1898–1972).
Mesquita principally devoted himself to art, experimenting with various techniques and mediums. Though known primarily for his wood engravings, he also produced etchings, lithographs, watercolors and drawings. Most notable are his birds, exotic animals, plants and flowers, and fantastical representations, both humorous and grim.